Basic Information

Reference Number

cb-485-17155936

Issuing Organization

National Research Council of Canada (NRC)

Solicitation Type

RFP - Request for Proposal (Formal)

Solicitation Number

25-58185

Title

High throughput device for rapid cellular metabolic characterization

Source ID

PWGSC

Agreement Type

Canadian Free Trade Agreement (CFTA)

Details

Location

Canada

Dates

Publication

2025/10/29 12:00:00 AM EDT

Closing Date

2025/11/25 02:00:00 PM EST

Contact Information

Veronica Exari

(343) 576-3252

Veronica.Exari@nrc-cnrc.gc.ca

Description

Description:

OBJECTIVE:
The cell culture scale-up team (CCSU) has a requirement for an instrument for rapid cellular metabolic characterization. The instrument will be used to characterize and screen the phenotype and the metabolic requirements of cell lines developed at the NRC and used in large-scale bioreactors.

BACKGROUND:
Cell lines can be used to produce monoclonal antibodies, recombinant proteins, viral vectors, vaccines, viruses and virus-like-particles. In large-scale bioreactor, the metabolic profile of a cell line has a critical impact on its productivity. The presence of certain nutrients in the cell culture media is also a strong determinant of the cell line performance. Therefore, we are looking for an instrument that will enable measurements of multiple metabolites in parallel at 32oC to 37oC in live cells. We are particularly interested in measurements of metabolites involved in mitochondrial activity and respiration. We also need to screen different compounds that might improve cell growth and productivity in a high-throughput fashion.

All the deliverables must be received within 2 months after the contract award date.

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